![]() ![]() An original post by one Tumblr user is reblogged by another user by embedding a quote of the original post, link and publishing username in the repost, with the option of making a comment in reply to the previous post.Ī feature of this method that distinguishes Tumblr from Twitter is that less emphasis is placed upon reblogging only the original post, resulting in often highly stacked semi-threaded conversations which are indexed and interpreted by the Tumblr server in the presented manner. It is profile-driven and hierarchical in its facilitation of "reblogs". In 2007, Tumblr, a blogging service and network, launched. 'Reblog' was an open-source tool for individually-run blogs, with many early new media artists and bloggers using the tool to share content from one blog on another. Reblog was an open-source tool made at Eyebeam Art and Technology Center's R&D program, a team led by Jonah Peretti along with Michael Frumin, Michael Migurski, Alexander R. With the rise of micro-blogging in the latter 2000s, however, user moderation on front pages was de-emphasized as a feature in favor of "reblogs" on user profiles, which were usually taken by bloggers and news services as automatic endorsement of an original/linked post's currency, if not popular favor. Only in the mid-2000s was the "share via e-mail" solicitation accompanied or replaced by branded "sharing" buttons from various social news or bookmarking services at the time, giving bloggers and news services a seemingly more accurate metric for readership and traffic than ever before the issue of user moderation, however, gave bloggers and news services pause due to both real and alleged competition in moderation ranking of shared "front-page" posts. With the rise of the World Wide Web, it was not uncommon for webmasters, including major news service websites, to encourage readers of a post to share a link to the post with others on one's contact list. Reblogging (and the increased attention paid to the indexing and encouragement of reblogging) has become a major feature of many social networking sites and content-hosting services, and it has also become a potent means of secondary content promotion and audience measurement whereby links to external content are syndicated across multiple profiles and the reposts are indexed as a measurement of currency and relevance.Ī historical precedent to reblogging is the viral nature of e-mail, as " Internet petitions" and " chain e-mails" which encouraged e-mail users to "resend" the e-mail to at least a minimum number of contacts on one's contact list were highly popular (and highly controversial) in the 1980s and 1990s. Tumblr then built it into their social network for re-sharing posts within the network, and similar features ("Retweet" on Twitter, "Share" on Facebook) then followed.įor a number of microblogging and social networking services, reblogging has become a means of both social bookmarking and user commentary unlike social news services like Digg, Slashdot, and Reddit, however, reblogging typically does not involve a centralized "front page" to which the highest-ranked post is appended. ![]() It was first developed by Jonah Peretti at Eyebeam Art and Technology Center's R&D program under the project 'Reblog' (from where the term originates) as an open-source tool for individually-run blogs. Reblogging (or, in Twitter parlance, retweeting) is the mechanism in blogging which allows users to repost the content of another user's post with an indication that the source of the post is another user. ![]()
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![]() ![]() Press the function (fn) key twice to launch Dictation on your Mac, start speaking, and press fn once you’ve finished. You can also use Option-Shift to change display brightness in small amounts. Press Option-Shift and volume up/down to increase or decrease the volume on your Mac in small increments. The easiest way to see all your open tabs in one Safari window. Navigate between multiple tabs using the Command-Shift-] or Command-Shift-[ characters. Hit Command and the left arrow to go back a page in the browser window. A third way is to use Control-Tab and Control-Shift-Tab. You can achieve a similar result using Command-Up or Command-Down. Jump directly to the top or bottom of a web page using the Function key and the right (to the bottom of the page) or left (to the top of the page) arrows on the keyboard. Show or hide the Dock from within most apps. Open application switcher, keeping Command pressed, use Tab to navigate to the app you hope to use. The fastest way to make a search or navigate to a Website in Safari, Command-L instantly selects the address bar: start typing your query, and select the appropriate choice using the up/down arrows on the keyboard. (I guess you know about Command-tab already?) Command-L The combination that can change your life, Command-Space invokes Spotlight, just depress these keys and start typing your query. Select this combination when in Finder/Desktop view to get to your Applications folder, or replace the A with U to open your Utilities folder in a new Finder window (or D for Desktop, H for Home or I to access iCloud Drive). You may just want to get to all the open windows for a specific app, in which case hold down the same keys and click on any available window for that app. If you can’t see your desktop for all the open applications, just hold Command and Option down and click anywhere on your desktop. Press this combination to minimize the front app window to Dock, or press Command-Option-M to minimize all the windows belonging to the front app. Oh, and you can also press Shift-Command-G to move back to the previous mention. This means that if you use Command-F to find all the mentions of 'Command' on this page, and then tap Command-G, you'll be able to navigate through each one. Use it to navigate through each instance of the item you want to find. ![]() I'm sure you use Command-F to find items, such as words in a document or on a webpage. Or you can simply press Command-, (comma) to get to them in the fastest possible time. You can navigate to the Menu bar if you like and scroll through to access the Preferences. It works like this: You are working in an app, and you want to open the application’s Preferences. This is one of the least-known keyboard commands on a Mac, but it’s super useful. There’s also a keyboard shortcut - select an item (you can even use the Up and Down arrows to navigate to it in Finder view) and then press Command-Y. To use QuickLook, select an item in Finder, press the Space bar and a preview will appear. Use Option-Command-W to close all currently active app windows.Ī lot of people use QuickLook to preview items they're looking for. Closes the active window you are currently in. ![]() ![]() ![]() We recently showed that SIRT6 is a DNA damage sensor that can recognize Double Strand Breaks (DSB) and initiate the DNA damage response for both homologous recombination and non-homologous end joining. Furthermore, male mice overexpressing SIRT6 display an increased lifespan, suggesting that SIRT6 has critical roles in the regulation of age-related pathologies. SIRT6 knockout mice showed accelerated aging and premature death by three weeks of age, accompanied by metabolic defects, genomic instability, and a progeroid-like phenotype. Particularly, the absence of SIRT6 results in neurodegeneration, heart disease, inflammation, diabetes, and more. In addition, several age-related diseases have been associated with the lack of Sirtuins. For example, Sirtuins play major roles in metabolism and have been implicated in the improvement of CR response in aging. To understand the molecular mechanism of aging, several genes have been studied – specifically, the Sirtuin deacylase and ADP-ribosylase gene family, which are highly conserved proteins with important roles in preventing age-related diseases. Nevertheless, the underlying mechanism is still under debate. The effects of CR are documented in various model organisms including worms, flies, mice and the primate rhesus monkey, suggesting that these effects are translatable into humans. Among the few successful treatments to delay aging, Calorie Restriction (CR) has been proven successful in extending lifespan and alleviate some of the detrimental effects of aging, such as cardiovascular disease, insulin resistance, and increased oxidative damage. Suddenly (in evolutionary terms), aging people have to deal with new health threats and the maintenance of organismal function for longer times, as more persons survive much longer than before. As a result, the mean life expectancy increased from 40-45 years before the modern era to 78.8 nowadays, mostly due to decreased rates of infant mortality, improved medical care, and favorable environmental conditions. Technological advances over the last centuries have drastically changed the environment in which humans evolved. ![]() Therefore, reduced SIRT6 activity may drive pathological age-related gene expression signatures in the brain.ĭuring aging, there is an increase in the incidence of several age-related diseases including neurodegeneration, in which aging itself is the main risk factor. We thus argue that SIRT6 has a pivotal role in preventing age-related transcriptional changes in brains. One of these candidates is YY1, which we found to act together with SIRT6 regulating specific processes. We found that each of these gene expression categories is associated with specific transcription factors, thus serving as potential candidates for their category-specific regulation. Our results define four gene expression categories that change with age in a pathological or non-pathological manner, which are either reversed or not by CR. In addition, we traced these differences in human and mouse samples of Alzheimer’s and Parkinson’s diseases, healthy aging and calorie restriction (CR). To understand SIRT6 roles in transcript pattern changes, we analyzed transcriptomes of young WT, old WT and young SIRT6-KO mice brains, and found changes in gene expression related to healthy and pathological aging. In the aging brain, SIRT6 levels/activity decline, which is accentuated in Alzheimer’s patients. Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. ![]() ![]() Twi-thought (n.) A vague or indistinct thought. Sardonian (n.) One who flatters with deadly intent. Ruffing (n.) The stomping of feet as a form of applause. Mafflard (n.) A stuttering or blundering fool. ![]() Grinagog (n.) A person who is constantly grinning. Gobemouche (n.) One who believes anything, no matter how absurd. Goat-drunk (adj.) Made lascivious by alcohol. (A favourite of mine.)įelicificability (n.) Capacity for happiness. Widdershins (also withershins): counterclockwise, contraryĬan I recommend Ammon Shea’s ‘Reading the OED’ as worthwhile source of delightful, if a little archaic and seldom-used words, e.g.,īemissionary (v.) To annoy with missionaries. Whirligig: whirling toy merry-go-round dizzying course of events Tatterdemalion: raggedly dressed person looking disreputable or decayed Swashbuckler: cocky adventurer story about the same Squelch: to suppress or silence act of silencing sucking sound Rigmarole (also rigamarole): confused talk complicated procedure Pettifogger: quibbler disreputable lawyer Periwinkle: light purplish blue creeping plant aquatic snail Obloquy: condemning or abusive language, or the state of being subject to such Loggerheads (in the expression “at loggerheads”): quarrelsome Lackadaisical: bereft of energy or enthusiasm Jackanapes: impudent or mischievous person High jinks (also hijinks): boisterous antics Higgledy-piggledy: in a disorganized or confused manner Haberdasher: men’s clothier provider of sundries Gobbledygook: nonsense, indecipherable writing Imbue your musings with mirth by incorporating these terms:Ībstemious: restrained in consumption of food and alcoholĬahoots (in the expression “in cahoots with”): schemingĬallipygian: possessing a shapely derriereĬopacetic (also copasetic, copesetic): satisfactoryĬurmudgeon: ill-tempered (and often old) personįactotum: all-around servant or attendantįestoon: to decorate dangling decorative chains ![]() Though their meanings may be obscure, they each present a challenge - I mean an opportunity - for you to paint a vivid word picture. Here are 100 words it’s difficult to employ without smiling. My dad always bibbles when he eats, I cannot stand to sit at the table whilst he has his dinner.Ī brouhaha is a situation which is chaotic or noisy.The English language can be maddening to native speakers and learners alike, but is also delightfully rich, especially for those who seek to convey a lighthearted tone in their writing.When used in a sentence, it might look something like this: To bibble is to eat or drink in a noisy fashion, often at the annoyance of those around you. Donald Trump is the worst president the USA has ever seen, he is a huge snollygoster.You may hear it being used in a sentence such as this one: This very funny-sounding word is used to refer to a politician who makes decisions for their own benefit and not for the benefit of the wider community. I don’t know how much longer I can work with Sam, he is such a flibbertigibbet.This word has been used in the English language for hundreds of years and you might hear it being used in the following context. I cannot be dealing with this malarky for a second longer.Ī flibbertigibbet is a person who talks a lot or is a little silly.You might see it being used in a sentence such as the following one: ![]() This commonly used word refers to a situation which is madness or chaotic. It’s very difficult taking my daughter to the shops since she spends a lot of time lollygagging rather than doing what she is supposed to.The word has long been used in the English language and might be heard in a sentence such as this one: ![]() To lollygag means to mess around or to waste time. My brother is a nice enough guy, but he is a bit of a gubbins.You can see it used in a sentence such as the following: It might also be used to talk about someone who is silly. The word gubbins is one which refers to something that is seen as rubbish or useless. When used in a sentence, you might hear the following: But in reality, it is referring to a type of knife from the 1700s. On first hearing, you might think that this word is something sweet. You might hear it being used in a sentence such as: It is a word which refers to something that is misaligned. The word cattywampus is most commonly used in the USA, especially the southern states. He speaks in very long sentences, which tends to bumfuzzle the children in the class.You might see it being used in a sentence such as this one: This ridiculous-sounding word which means to be confused. We will take a look at the word as well as exploring what it means and how it might be used within a sentence. Let’s begin exploring some of the most funny-sounding words that can be found in the English language. The 10 Funnies Words in The English Language ![]() ![]() ![]() The standard 10X Genetics workflow was used. An asymetrical sequencing profile is used to sequence stand alone 10X single cell 5 libraries. Each chip can process 8 samples at once, capturing 80,000 in less than 20 minutes. Single Cell Multiome ATAC v2 + 3' Gene Expression v3. Cells were then delivered immediately to the MGH NextGen Sequencing Core Facility and core staff prepared cDNA libraries using the 10X Genetics v3.0 kits. Immunology Neurology Stem Cell Biology Immuno-oncology Infectious disease Single cell libraries prepared using the 10X Chromium Controller are Illumina compatable and will be sequenced using the NovaSeq 6000. The 10X Chromium Controller generates thousands of single cell nano-reactions to barcode up to 10,000 cells per lane for high throughput single cell analysis. Sample #2 - #8 : Human or Mouse / T cell or B cell Sample #1 : Human or Mouse / T cell or B cell Single Cell 5' Expression Library v2 + V(D)J Immune Enrichment Single Cell 5' Expression v2 V(D)J Library The sample #1 cost is applicable for each 10X Chromium Chip required. The average affiliate pricing per sample is $2050.63 for Single Cell 3' expression, $2050.63 for Single Cell 5' expression, $2065.63 for Single Cell V(D)J immune profiling, $2135.63 for Single Cell 5' Expression + V(D)J immune profiling, $1975.63 for ATAC and $3350.63 for Single Cell Multiome ATAC + 3' Gene Expression when performing an 8 sample project. The tiered cost structure for 10X Chromium Controller library preparation is structured to obtain cost recovery on the single use 8 sample 10X Chromium Chip. Targeted cell/nuclei counts and reads per cell/nuclei are project specific and will determine the sequencing required and the associated cost. In one application, the instrument uses synthetic gel beads to partition thousands of separate enzymatic reactions necessary for downstream DNA sequencing. The MGH NextGen Sequencing Core Core Services PRICING Overview Basic pricing for NextGen library construction and sequencing services is given below. using the 10X Genomics Chromium Controller Instrument (10X Genomics. provides two unique key technologies to the UF research community. 1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142. ![]() Analyze full length paired B-cell or T-cell receptors, surface protein expression, antigen specificity, and gene expression, all from a single cell.Ĭhromium Single Cell ATAC (Assay for Transposase Accessible Chromatin) allows you to analyze chromatin accessibility at the single cell level, providing insights into cell types and states, and deeper understanding of gene regulatory mechanisms.The pricing for 10X Chromium Controller library preparations does not include sequencing cost on the NovaSeq 6000. The Chromium instrument developed by California-based 10X Genomics inc. Explore cellular heterogeneity, identify rare cell types, novel targets, biomarkers, cell types and states.Ĭhromium Single Cell Immune Profiling provides a multiomic solution to your immunology questions. Please contact information about technical procedures, library prep and more and Rita Holdhus at the Genomics Core facility for sequencing.Ĭhromium Single Cell Gene Expression provides single cell transcriptome 3’ gene expression profiles from hundreds to tens of thousands of cells. From assessing tumor heterogeneity and stem cell composition, to dissecting neuronal populations-the technological advancements provided by the Chromium Single Cell Gene Expression Solution, along with turnkey software tools, allow you to maximize insight from any sample type 1.įor more information about the technology, please visit 10X Genomics and the broshure The Power of Single Cell PartitioningĪ checklist of the materials required can be found at the bottom of the page. Go beyond traditional gene expression analysis to characterize cell populations, cell types, cell states, and more on a cell-by-cell basis. Our latest improvements vastly increase sensitivity, so you can detect even more unique transcripts per cell 1. The Chromium Single Cell Gene Expression Solution provides an unparalleled approach to uncover cell-to-cell gene expression variability and identify rare cell types from complex biological samples. Until recently, most molecular studies have relied on bulk analysis, combining all cells into a single average readout. The power of dissecting cell-type differences in complex biological systems is critical to our understanding of cellular contributions during development and in disease progression. The Chromium X Series is compatible with all of the company’s existing low throughput and standard single cell assays and is supported by the 10x Genomics Cloud Analysis offering for data. ![]() ![]() The bookmark icon to the left of any filter box allows you to apply some pre-made filters. If you have a lot of packets in the capture, this can take some seconds. If instead, the filter is correct, you will have to press enter and the output will be trimmed. In case you don’t, it simply won’t work and won’t allow you to press enter. Now, to apply a Wireshark display filter you need to write a correct one. You can write capture filters right here. From this window, you have a small text-box that we have highlighted in red in the following image. This will open the panel where you can select the interface to do the capture on. To apply a capture filter in Wireshark, click the gear icon to launch a capture. Let’s start with the capture filter, as it is the first one that you can apply. You have two different places to write filters, one for capture filters and the other for display filters. However, since you are capturing all traffic, you can quickly create large Wireshark files, hard to manage. This can be useful in troubleshooting, as you can search for stuff by changing the filter multiple times. In fact, it will just hide the traffic that doesn’t match but never delete it. ![]() This will affect what you see on the screen, but not what you capture. You can even apply it while the capture is running. You can apply that to a capture you already made, then cancel the filter and apply another. You can’t even retrieve them later on, you just don’t see this traffic.Ī display filter is exactly what the name says. Instead, keep in mind that traffic that doesn’t match won’t be visible. As you can see, this is very useful if you want to see some specific traffic, but you are working in a production network where a lot of traffic is flowing. All the traffic that doesn’t match will be discarded, and never stored on your PC. Then, when launching the capture, Wireshark will capture only the traffic matching the filter. If you want to create a capture filter, you have to do it before starting the capture. ![]() They have the exact same syntax, what changes is the way they are applied. Wireshark supports two types of filters: capture filter and display filter. Don’t worry, we are going to crack it down. ![]() Instead, we will have to use a very specific syntax with some strict rules. As you can imagine, Wireshark doesn’t allow us to write such friendly sentences. It is something that looks like “I want to see only HTTP traffic” or “I’d like to see only traffic to and from host X”. Wireshark Filter, a quick introduction What is a Wireshark Filter?Īll in all, a Wireshark Filter is just a piece of text. You will find some very useful Wireshark Filter ready to use, copy-and-paste. ![]() If that’s what you want, just scroll down to the end of the article. In this article, we will learn how to create and apply an effective Wireshark filter in our captures. These Wireshark filters tell the software what we want to see, hiding everything else. This can quickly become messy unless we use a Wireshark Filter. Therefore, you will have to deal with tons of information, particularly in a production network. However, as we have seen in the previous article, it literally collects all the traffic. To do that, it shows you all the traffic you send and receive on a Network interface. Wireshark is a powerful tool: it allows you to see what’s going on in a network. ![]() ![]() ![]() Guia do usuário incluído e apoio VSO garantidas para seus problemas de menor. ConvertXtoDVD está disponível em vários idiomas. Configure suas configurações favoritas de chamas. 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